James D. Wolfe, MD - Allergy and Asthma Associates of Northern California | San Jose Allergists
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San Jose Main Office: 408-243-2700 • South San Jose: 408-281-7400 • Regional East San Jose: 408-254-0300 • Santa Cruz: 831-479-6933 • Gilroy: 408-848-1800 • Fremont: 510-797-5555 • Monterey: 831-649-4044 • Mountain View: 650-210-9292

James D. Wolfe, MD

James D. Wolfe, MD, with Allergy and Asthma Associates of Northern California

Dr. James Wolfe is the senior member of Allergy and Asthma Associates, where he has been dedicated to the care of patients with a variety of allergic disorders for more than 40 years. During this time, he has contributed regularly to the education of medical residents from Stanford Medical School and Santa Clara Valley Medical Center and has been involved in medical research, performing over 400 clinical studies that led to the approval of nearly all medications currently utilized to treat asthma and allergic disorders. Dr. Wolfe, along with several colleagues, created the pharmaceutical company AllerQuest that provides all allergists and hospitals with the FDA-approved penicillin skin test to evaluate the large number of patients with reported penicillin allergy.

Dr. Wolfe is very proud of his wife's work with a non-profit dedicated to rare childhood cancers, and for what his two adult children have accomplished to improve the well-being of those facing health and other life challenges. Dr. Wolfe is an avid swimmer, enjoys reading and hiking, traveling with his wife, and being involved in the care of his mother and mother-in-law who are both centenarians.

Board Certification

  • American Board of Allergy and Immunology
  • American Board of Pulmonary Diseases


  • Fellowship in Allergy and Immunology: Johns Hopkins University
  • Fellowship in Pulmonary Diseases: UCLA
  • Residency in Medicine: UCLA
  • Medical School: UCSF School of Medicine

Professional Organizations & Affiliations

  • Clinical Professor of Medicine, Stanford University School of Medicine
  • Chairman of the Allergy and Immunology Division at Santa Clara Valley Medical Center for 27 years
  • President, Allergy and Asthma of SCV Research Center
  • President, AllerQuest Pharmaceutical
  • Faculty, Stanford-O'Connor Family Residency Program
  • Member, UCSF-Benioff Community Physicians


  • Phi Beta Kappa
  • AOA Honor Medical Society
  • Selected to Best Doctors in America, 1996 - present
  • Excellence in Teaching Award, Stanford-O'Connor Family Medicine Residency Program, 2007
  • Santa Clara County Medical Association Award for Outstanding Contribution in Medical Education, 2015
  • Special Recognition Award by the American College of Allergy, Asthma and Immunology for work related to penicillin allergy, 2019


Senior author on extensive publications addressing the use of new medications for the treatment of asthma and allergic disorders including in the New England Journal of Medicine, JAMA, Chest, Journal of Allergy and Clinical Immunology, and American Review of Respiratory and Critical Care Medicine.

Read Dr. Wolfe's latest article on "Am I Food Allergic?."

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Office Locations

James D. Wolfe, MD, sees patients at the following offices.


San Jose - Main Office

4050 Moorpark Ave,
San Jose, CA 95117


Map & Directions


South San Jose Office

393 Blossom Hill Road,
Suite 315,
San Jose, CA 95123


Map & Directions


Santa Cruz Office

3329 Mission Drive,
Santa Cruz, CA 95065


Map & Directions

In-Office & Telemedicine Appointments Available! Request Appointment

Eight Convenient Bay Area Offices

  • South San Jose393 Blossom Hill Rd
    Suite 315
    San Jose, CA 95123
  • 404-281-7400
  • Santa Cruz3329 Mission Dr
    Santa Cruz, CA 95065
  • 831-479-6933
  • Gilroy9360 No Name Uno
    Suite 250
    Gilroy, CA 95020
  • 408-848-1800
  • Fremont2287 Mowry Ave
    Suite E
    Fremont, CA 94538
  • 510-797-5555
  • Monterey337 El Dorado St
    Suite 2A
    Monterey, CA 93940
  • 831-649-4044
  • Mountain View285 South Dr
    Suite 1
    Mountain View, CA 94040
  • 650-210-9292